It is often suggested that during development the brain barriers are immature. This argument stems from teleological interpretations and experimental observations of the high protein concentrations in fetal cerebrospinal fluid (CSF) and decreases in apparent permeability of passive markers during development. We argue that the developmental blood–CSF barrier restricts the passage of lipid‐insoluble molecules by the same mechanism as in the adult (tight junctions) rendering the paracellular pathway an unlikely route of entry. Instead, we suggest that both protein and passive (...) markers are transferred across the epithelium through a transcellular route. We propose that changes in volume of distribution can largely explain the decrease in apparent permeability for passive markers and that developmentally regulated cellular transfer explains changes in CSF protein concentrations. The blood–CSF tight junctions are functionally mature from very early in development, and it appears that transfer from blood into embryonic brain occurs predominately via CSF rather than the vasculature. BioEssays 30:237–248, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

“…we are left with a choice between saying that Mark was simply incompetent, or that the ending, though strange, is right if rightly (finely) interpreted. We have to explain why a book that begins so triumphantly and makes promises of a certain kind ends in silence and dismay, without fulfilling the promises.”1 (Frank Kermode.).

Socratic philosophy represents a long-standing tradition within philosophy that understands the journey to truth in terms of the traveler's innate capacity. Anamnesis, maieutics, and elenchus each confirm that truth is not utterly foreign but is instead always within my possession or grasp. Other people, to the extent that they participate in my philosophical exploration, serve only to enable my capabilities or potential. They are not teachers to me. Nor would I need them, since I am always already in the neighborhood (...) of truth. ;Emmanuel Levinas's description of the "face to face" encounter between people challenges the adequacy of this model. Another person is not simply a midwife who leads me to a recovery of truth that was always within me or within my domain. Rather, the Other comes to me from a dimension of height or transcendence and teaches me. By this teaching Levinas means that I, as one who might claim truth for myself, find myself put into question. Before the Other I discover that my claims to knowledge are inadequate, even unjust, insofar as the Other exceeds, and thereby resists, my comprehensive claim on the world. The Other, in other words, reveals the naivete and the dogmatism characteristic of my familiar world, and puts me on a new and unforseen path to truth. ;This dissertation, by way of an explication of the category of transcendence, examines how the autonomous world of Socratic maieutics is transformed by the teaching encounter with another person into a heteronomous world. Heteronomy suggests my answerability to an order beyond the resources of anamnesis. This answerability, which Levinas describes as my responsibility to the Other, demands that we re-examine language not in terms of its systematicity or thematic capability but as the condition for all speaking whatsoever, i.e., my being called into communication. The word of the Other signifies a transcendent domain, a domain beyond my familiar world. It also makes possible a sincere life lived to the Other. (shrink)

The Mental Capacity Act 2005 gives statutory force to the common law principle that all adults are assumed to have capacity to make decisions unless proven otherwise. In accord with best practice, this principle places the evidential burden on researchers rather than participants and requires researchers to take account of short-term and transient understandings common among some research populations. The aim of this paper is to explore some of the implications of the MCA 2005 for researchers working with 'vulnerable' populations (...) in health and social care settings. The Cyclical Consent Model is described and offered as a process by which researchers might develop good practice when engaged in research involving vulnerable people. (shrink)

Dienes & Perner make three mistakes in their account of the “natural language meaning” of implicit-explicit knowledge: They fail to take the multiplicity of use of a concept seriously enough, they arbitrarily separate use of a concept and its conceptual structure, and they tend to tailor their analysis for use by the Representational Theory of Knowledge.

Until the discovery of catalytic RNA, the notion that all enzymes are proteins had seemed incontrovertible. Now the existence of RNA enzymes has been confirmed in a variety of contexts. What is known about the chemistry of RNA‐catalyzed reactions is reviewed below, with particular attention to the self‐splicing rRNA intron of Tetrahymena thermophila and the processing of pre‐tRNA molecules by RNase P.

Alexandre Grothendieck foi um dos maiores matemáticos do século 20 e um dos mais atípicos. Nascido na Alemanha a um pai anarquista de origem russa, sua infância foi marcada pela militância política dos seus pais, assim passando por revoluções, guerras e sobrevivência. Descoberto por sua precocidade matemática por Henri Cartan, Grothendieck fez seu doutorado sob orientação de Laurent Schwartz e Jean Dieudonné. As principais contribuições dele são na área da topologia e na geometria algébrica, assim como na teoria das categorias. (...) No final dos anos de 1960, ele se dedicou à militância política e ecológica, organizando a revista Survivre durante três anos. Em 1986, publicou um manuscrito autobiográfico de 1000 páginas, Récoltes et semailles, em que ele descreve sua experiência e sua prática da matemática, assim suas contribuições à comunidade matemática francesa. Pouco comentado na filosofia, as implicações dos seus descobrimentos fora mais recentemente discutidas por Alain Badiou na sua "fenômeno-lógica", em Logiques des mondes e Arkady Plonitsky, Mathgematics, Science and postclassical Theory, pesquisa trata da semelhança entre os aspectos formais da filosofia de Gilles Deleuze e da topologia de Grothendieck. (shrink)

In this article, we report the results of a survey of North American adults (n= 1,215) conducted between March 24 and 30, 2020 at the onset of the COVID-19 pandemic. Respondents completed the COVID-TIS (Transitional Impact Scale-Pandemic version) and the 21-item Depression, Anxiety, and Stress Scale (DASS), indicated their level of COVID-infection concern for themselves and close others, and provided demographic information. The results indicated: (a) during its early stage, the pandemic produced only moderate levels of material and psychological change; (...) (b) the pandemic produced mild to moderate levels of psychological distress; (c) respondents who lost their jobs as a result of the pandemic experienced more change and more psychological distress than those who did not, and (d) younger respondents and less well-educated ones experienced more psychological distress than older respondents. Unexpectedly, (e) respondents indicated that they were more concerned that friends and family members would become infected with COVID-19 than that they would be. We conclude by speculating that these results are driven less by the immediate changes brought about by the pandemic and more by uncertainty concerning its long-term economic and social impact. (shrink)

Index to the Digha-nikaya. Compiled by M. Yamazaki, Y. Ousaka, K. R. Norman and M. Cone. Pali Text Society, Oxford 1997. vii, 357 pp. £19.75. ISBN 0 86013 355 9.

We discuss five kinds of representations of rationales and provide a formal account of how they can alter disputation. The formal model of disputation is derived from recent work in argument. The five kinds of rationales are compilation rationales, which can be represented without assuming domain-knowledge (such as utilities) beyond that normally required for argument. The principal thesis is that such rationales can be analyzed in a framework of argument not too different from what AI already has. The result is (...) a formal understanding of rationales, a partial taxonomy, and a foundation for computer programs that represent and reason with rationales.The five kinds of rationales are as follows: (c)ompression and (s)pecialization, which yield rules, and (d)isputation, which yields a decision. These are modeled as potentially changing the focus of the dispute. Then there are (f)it, a rationale for rules, and (r)esolution, a rationale for decisions. These cannot be modeled as simply; they force disputation to a meta-level, at least temporarily. (shrink)